Pattern Formation: Gurken meets torpedo for the first time
نویسنده
چکیده
Intercellular communication between oocyte and follicle cells, mediated by the gurken-torpedo/DER signalling pathway, has a crucial role in determining both anterior-posterior and dorsal-ventral polarity in Drosophila.
منابع مشابه
cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila
In Drosophila, the dorsal-ventral polarity of the egg chamber depends on the localization of the oocyte nucleus and the gurken RNA to the dorsal-anterior corner of the oocyte. Gurken protein presumably acts as a ligand for the Drosophila EGF receptor (torpedo/DER) expressed in the somatic follicle cells surrounding the oocyte. cornichon is a gene required in the germline for dorsal-ventral sign...
متن کاملSequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis.
Previous work has demonstrated a role for the Drosophila EGF receptor (Torpedo/DER) and its ligand, Gurken, in the determination of anterioposterior and dorsoventral axes of the follicle cells and oocyte. The roles of DER in establishing the polarity of the follicle cells were examined further, by following the expression of DER-target genes. One class of genes (e.g. kekon) is induced by the DE...
متن کاملThe relationship between ovarian and embryonic dorsoventral patterning in Drosophila.
In Drosophila, the dorsoventral asymmetry of the egg chamber depends on a dorsalizing signal that emanates from the oocyte. This signal is supplied by the TGF alpha-like gurken protein whose RNA is localized to the dorsal-anterior corner of the oocyte, gurken protein is the potential ligand of the Drosophila EGF receptor homolog (torpedo), which is expressed in the follicular epithelium surroun...
متن کاملModels for positional signalling with application to the dorsoventral patterning of insects and segregation into different cell types.
Models of pattern formation and possible molecular realizations are discussed and compared with recent experimental observations. In application to the dorsoventral patterning of insects, it is shown that a superposition of two pattern-forming reactions is required. The first system generates the overall dorsoventral polarity of the oocyte, the second generates the positional information proper...
متن کاملPost-transcriptional regulation of gurken by encore is required for axis determination in Drosophila.
Establishment of anterior-posterior and dorsal-ventral polarity within the Drosophila egg chamber requires signaling between the germline and the somatic cells of the ovary. The gene gurken (grk) encodes a TGFalpha-like protein that is localized within the developing oocyte and is thought to locally activate torpedo/Egfr (top/Egfr), the Drosophila homolog of the EGF receptor, which is expressed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 5 شماره
صفحات -
تاریخ انتشار 1995